Assay Detail
ADMET
CHEMBL5329968
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Inhibition of human CYP11B1 stably transfected in mouse Y-1 cells using deoxycortisol or deoxycorticosterone as substrate incubated for 48 hrs by radioimmuno assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Y-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.68 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406728 | — | — | 1 | 8.42 |
| CHEMBL5394924 | — | — | 1 | 7.86 |
| CHEMBL5439285 | — | — | 1 | 7.73 |
| CHEMBL5415822 | — | — | 1 | 7.65 |
| CHEMBL5415328 | — | — | 1 | 7.62 |
| CHEMBL5410752 | — | — | 1 | 7.47 |
| CHEMBL5423538 | — | — | 1 | 7.41 |
| CHEMBL5413320 | — | — | 1 | 7.40 |
| CHEMBL5396904 | — | — | 1 | 7.34 |
| CHEMBL5424502 | — | — | 1 | 7.33 |
| CHEMBL5424651 | — | — | 1 | 7.27 |
| CHEMBL5418063 | — | — | 1 | 7.23 |
| CHEMBL5402622 | — | — | 1 | 7.11 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 7.10 |
| CHEMBL5409957 | — | — | 1 | 7.09 |
| CHEMBL5408774 | — | — | 1 | 7.07 |
| CHEMBL5396680 | — | — | 1 | 7.04 |
| CHEMBL5397427 | — | — | 1 | 6.92 |
| CHEMBL5408597 | — | — | 1 | 6.91 |
| CHEMBL5424888 | — | — | 1 | 6.83 |
| CHEMBL5413659 | — | — | 1 | 6.77 |
| CHEMBL5400111 | — | — | 1 | 6.71 |
| CHEMBL5426410 | — | — | 1 | 6.69 |
| CHEMBL5431649 | — | — | 1 | 6.62 |
| CHEMBL5415158 | — | — | 1 | 6.61 |
| CHEMBL5417708 | — | — | 1 | 6.59 |
| CHEMBL5426685 | — | — | 1 | 6.57 |
| CHEMBL5414558 | — | — | 1 | 6.54 |
| CHEMBL5412539 | — | — | 1 | 6.53 |
| CHEMBL5401923 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406728 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5394924 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL5439285 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL5415822 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL5415328 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL5410752 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL5423538 | — | IC50 | = | 38.6 | nM | 7.41 |
| CHEMBL5413320 | — | IC50 | = | 40.1 | nM | 7.40 |
| CHEMBL5396904 | — | IC50 | = | 45.9 | nM | 7.34 |
| CHEMBL5424502 | — | IC50 | = | 46.2 | nM | 7.33 |
| CHEMBL5424651 | — | IC50 | = | 53.4 | nM | 7.27 |
| CHEMBL5418063 | — | IC50 | = | 59.3 | nM | 7.23 |
| CHEMBL5402622 | — | IC50 | = | 77.3 | nM | 7.11 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 79.1 | nM | 7.10 |
| CHEMBL5409957 | — | IC50 | = | 81.1 | nM | 7.09 |
| CHEMBL5408774 | — | IC50 | = | 85.8 | nM | 7.07 |
| CHEMBL5396680 | — | IC50 | = | 91.7 | nM | 7.04 |
| CHEMBL5397427 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5408597 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5424888 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5413659 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL5400111 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5426410 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL5431649 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL5415158 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5417708 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL5426685 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5414558 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL5412539 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL5401923 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL5412612 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL5420175 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL5432000 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL5437875 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL5405763 | — | IC50 | = | 588.0 | nM | 6.23 |
| CHEMBL5398781 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL5405085 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL5438181 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL5433146 | — | IC50 | = | 764.0 | nM | 6.12 |
| CHEMBL5416314 | — | IC50 | = | 801.0 | nM | 6.10 |
| CHEMBL5409569 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5394552 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL5396271 | — | IC50 | = | 932.0 | nM | 6.03 |
| CHEMBL5430478 | — | IC50 | = | 964.0 | nM | 6.02 |
| CHEMBL5410140 | — | IC50 | = | 1184.0 | nM | 5.93 |
| CHEMBL5420707 | — | IC50 | = | 1448.0 | nM | 5.84 |
| CHEMBL5407517 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5421803 | — | IC50 | = | 1666.0 | nM | 5.78 |
| CHEMBL5420100 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5418651 | — | IC50 | = | 2130.0 | nM | 5.67 |