Assay Detail
ADMET
CHEMBL5329971
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Inhibition of human CYP11B1 expressed in human NCI-H295 cells incubated for 48 hrs by radioimmuno assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NCI-H295 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.92 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413320 | — | — | 1 | 7.81 |
| CHEMBL5408597 | — | — | 1 | 7.68 |
| CHEMBL5402622 | — | — | 1 | 7.62 |
| CHEMBL5409957 | — | — | 1 | 7.61 |
| CHEMBL5413659 | — | — | 1 | 7.32 |
| CHEMBL5417708 | — | — | 1 | 7.25 |
| CHEMBL5414558 | — | — | 1 | 7.19 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 6.99 |
| CHEMBL5418063 | — | — | 1 | 6.97 |
| CHEMBL5400111 | — | — | 1 | 6.81 |
| CHEMBL5412612 | — | — | 1 | 6.80 |
| CHEMBL5398781 | — | — | 1 | 6.64 |
| CHEMBL5420707 | — | — | 1 | 6.59 |
| CHEMBL5426685 | — | — | 1 | 6.56 |
| CHEMBL5401923 | — | — | 1 | 6.49 |
| CHEMBL5405085 | — | — | 1 | 6.33 |
| CHEMBL5410140 | — | — | 1 | 6.33 |
| CHEMBL5438181 | — | — | 1 | 6.27 |
| CHEMBL5405763 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413320 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL5408597 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL5402622 | — | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL5409957 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL5413659 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL5417708 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5414558 | — | IC50 | = | 64.8 | nM | 7.19 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL5418063 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5400111 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5412612 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5398781 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL5420707 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL5426685 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL5401923 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL5405085 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL5410140 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL5438181 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL5405763 | — | IC50 | = | 595.0 | nM | 6.22 |