Assay Detail
Binding
CHEMBL5330108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to RIOK2 (unknown origin) assessed as dissociation constant by KINOMEscan assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase RIO2 (CHEMBL6000) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.39 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172767 | — | — | 1 | 8.14 |
| CHEMBL5399070 | — | — | 1 | 7.72 |
| CHEMBL5417058 | — | — | 1 | 7.32 |
| CHEMBL5417476 | — | — | 1 | 7.28 |
| CHEMBL5439857 | — | — | 1 | 7.25 |
| CHEMBL5406944 | — | — | 1 | 7.21 |
| CHEMBL5416400 | — | — | 1 | 6.78 |
| CHEMBL5411549 | — | — | 1 | - |
| CHEMBL5424801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172767 | — | Kd | = | 7.3 | nM | 8.14 |
| CHEMBL5399070 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL5417058 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL5417476 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL5439857 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL5406944 | — | Kd | = | 62.0 | nM | 7.21 |
| CHEMBL5416400 | — | Kd | = | 165.0 | nM | 6.78 |
| CHEMBL5411549 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL5424801 | — | Kd | > | 1000.0 | nM | - |