Assay Detail
Functional
CHEMBL5330114
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Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.50 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399070 | — | — | 1 | 5.90 |
| CHEMBL5172767 | — | — | 1 | 5.78 |
| CHEMBL5416400 | — | — | 1 | 5.42 |
| CHEMBL5417476 | — | — | 1 | 5.41 |
| CHEMBL5439857 | — | — | 1 | 5.39 |
| CHEMBL5411549 | — | — | 1 | 5.38 |
| CHEMBL5417058 | — | — | 1 | 5.36 |
| CHEMBL5406944 | — | — | 1 | 5.35 |
| CHEMBL5424801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399070 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5172767 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5416400 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL5417476 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL5439857 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL5411549 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL5417058 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL5406944 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL5424801 | — | IC50 | > | 10000.0 | nM | - |