Assay Detail
Functional
CHEMBL5330159
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Antitrypanosomal activity against of Trypanosoma cruzi epimastigotes in presence of FA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of the 2-arylquinazoline-4(3<i>H</i>)one scaffold for a selective and potent antitrypanosomal agent: modulation of the mechanism of action through chemical functionalization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.68 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408126 | — | — | 1 | 5.18 |
| CHEMBL5431637 | — | — | 1 | 4.72 |
| CHEMBL1163173 | — | — | 1 | 4.62 |
| CHEMBL5436408 | — | — | 1 | 4.60 |
| CHEMBL18688 | — | — | 1 | 4.48 |
| CHEMBL5407773 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408126 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL5431637 | — | IC50 | = | 19120.0 | nM | 4.72 |
| CHEMBL1163173 | — | IC50 | = | 24180.0 | nM | 4.62 |
| CHEMBL5436408 | — | IC50 | = | 25230.0 | nM | 4.60 |
| CHEMBL18688 | — | IC50 | = | 33210.0 | nM | 4.48 |
| CHEMBL5407773 | — | IC50 | = | 33130.0 | nM | 4.48 |