Assay Detail
Binding
CHEMBL5330541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor measured after 60 mins by competitive binding assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New aryl-/heteroarylpiperazine derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5,10-trione: Synthesis and preliminary studies of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.00 | 7.00 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422403 | — | — | 1 | 7.00 |
| CHEMBL5435378 | — | — | 1 | 7.00 |
| CHEMBL5395179 | — | — | 1 | 7.00 |
| CHEMBL5403228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422403 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5435378 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5395179 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5403228 | — | Activity | - | — | - |