Assay Detail
Functional
CHEMBL5330617
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral infection preincubated for 1 hr followed by incubation in methylcellulose medium for 25 to 26 hrs by TrueBlue based EliSpot analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Identification of Ebselen derivatives as novel SARS-CoV-2 main protease inhibitors: Design, synthesis, biological evaluation, and structure-activity relationships exploration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.26 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.42 |
| CHEMBL3920474 | — | — | 1 | 5.10 |
| CHEMBL5411764 | — | — | 1 | - |
| CHEMBL5409716 | — | — | 1 | - |
| CHEMBL5394951 | — | — | 1 | - |
| CHEMBL5398922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | EC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL3920474 | — | EC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL5411764 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5409716 | — | EC50 | > | 9910.0 | nM | - |
| CHEMBL5394951 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5398922 | — | EC50 | > | 13300.0 | nM | - |