Assay Detail
Binding
CHEMBL5331164
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Inhibition of human His-tagged tyrosinase CD expressed in HEK293 cells assessed as inhibition of melanin production using L-DOPA as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.25 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743159 | — | — | 1 | 6.05 |
| CHEMBL450195 | RUCINOL | — | 1 | 4.87 |
| CHEMBL537 | HYDROQUINONE | 4.0 | 1 | 4.82 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
| CHEMBL1086681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743159 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL450195 | RUCINOL | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL537 | HYDROQUINONE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 400000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | > | 4000000.0 | nM | - |
| CHEMBL1086681 | — | IC50 | = | 1200000.0 | nM | - |