Assay Detail
Functional
CHEMBL5331796
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Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.99 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 8.15 |
| CHEMBL5403133 | — | — | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 7.04 | nM | 8.15 |
| CHEMBL5403133 | — | IC50 | = | 14.79 | nM | 7.83 |