Assay Detail
Binding
CHEMBL5332633
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Inhibition of human recombinant FAAH using AMC-AA as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by multimode plate reader analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.11 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165084 | — | — | 1 | 8.43 |
| CHEMBL5401122 | — | — | 1 | 8.12 |
| CHEMBL5430250 | — | — | 1 | 8.08 |
| CHEMBL5417524 | — | — | 1 | 8.00 |
| CHEMBL5410254 | — | — | 1 | 7.98 |
| CHEMBL5432036 | — | — | 1 | 7.93 |
| CHEMBL5405509 | — | — | 1 | 7.81 |
| CHEMBL5420923 | — | — | 1 | 7.80 |
| CHEMBL5436635 | — | — | 1 | 7.58 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 7.51 |
| CHEMBL5429985 | — | — | 1 | 7.32 |
| CHEMBL2165094 | — | — | 1 | 6.99 |
| CHEMBL5440014 | — | — | 1 | 6.89 |
| CHEMBL5419246 | — | — | 1 | 6.78 |
| CHEMBL5403566 | — | — | 1 | 6.73 |
| CHEMBL5403865 | — | — | 1 | 6.71 |
| CHEMBL5419615 | — | — | 1 | 6.60 |
| CHEMBL5427155 | — | — | 1 | 6.50 |
| CHEMBL5396366 | — | — | 1 | 6.39 |
| CHEMBL5416058 | — | — | 1 | 5.98 |
| CHEMBL5419776 | — | — | 1 | 5.18 |
| CHEMBL5430706 | — | — | 1 | 5.07 |
| CHEMBL5412058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165084 | — | IC50 | = | 3.72 | nM | 8.43 |
| CHEMBL5401122 | — | IC50 | = | 7.54 | nM | 8.12 |
| CHEMBL5430250 | — | IC50 | = | 8.29 | nM | 8.08 |
| CHEMBL5417524 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL5410254 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL5432036 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5405509 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL5420923 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL5436635 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL184238 | URB-597 | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL5429985 | — | IC50 | = | 47.4 | nM | 7.32 |
| CHEMBL2165094 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL5440014 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5419246 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL5403566 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL5403865 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5419615 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL5427155 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5396366 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL5416058 | — | IC50 | = | 1044.0 | nM | 5.98 |
| CHEMBL5419776 | — | IC50 | = | 6556.0 | nM | 5.18 |
| CHEMBL5430706 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL5412058 | — | IC50 | > | 10000.0 | nM | - |