Compound Detail
CHEMBL5405509
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Basic Information
| ChEMBL ID | CHEMBL5405509 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DTNWASZZXLCBJW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
463.6
MW (Da)
4.57
ALogP
5
HBA
1
HBD
75.9
PSA (Ų)
0.56
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 7.81 | 7.81 | 15.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 15.6 | nM | 7.81 | Inhibition of human recombinant FAAH using AMC-AA as substrate preincubated for ... | 36462439 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36462439 | 10.1016/j.ejmech.2022.114952 | Fatty-acid amide hydrolase 1 | 1 |
| 36462439 | 10.1016/j.ejmech.2022.114952 | Monoglyceride lipase | 1 |
| 36462439 | 10.1016/j.ejmech.2022.114952 | Cannabinoid receptor 1 | 1 |
| 36462439 | 10.1016/j.ejmech.2022.114952 | Cannabinoid receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine