Assay Detail
Binding
CHEMBL5332634
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Inhibition of human recombinant MAGL using 7-hydroxycoumarinyl arachidonate as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by multimode plate reader analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.41 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420923 | — | — | 1 | 6.32 |
| CHEMBL5410254 | — | — | 1 | 5.61 |
| CHEMBL5429985 | — | — | 1 | 5.54 |
| CHEMBL5432036 | — | — | 1 | 5.39 |
| CHEMBL5430250 | — | — | 1 | 5.30 |
| CHEMBL5401122 | — | — | 1 | 5.08 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 5.03 |
| CHEMBL5419246 | — | — | 1 | 5.00 |
| CHEMBL5403566 | — | — | 1 | - |
| CHEMBL5396366 | — | — | 1 | - |
| CHEMBL5419776 | — | — | 1 | - |
| CHEMBL5436635 | — | — | 1 | - |
| CHEMBL5403865 | — | — | 1 | - |
| CHEMBL5430706 | — | — | 1 | - |
| CHEMBL5416058 | — | — | 1 | - |
| CHEMBL5427155 | — | — | 1 | - |
| CHEMBL5412058 | — | — | 1 | - |
| CHEMBL5417524 | — | — | 1 | - |
| CHEMBL5440014 | — | — | 1 | - |
| CHEMBL5419615 | — | — | 1 | - |
| CHEMBL5405509 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420923 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL5410254 | — | IC50 | = | 2437.0 | nM | 5.61 |
| CHEMBL5429985 | — | IC50 | = | 2899.0 | nM | 5.54 |
| CHEMBL5432036 | — | IC50 | = | 4116.0 | nM | 5.39 |
| CHEMBL5430250 | — | IC50 | = | 5061.0 | nM | 5.30 |
| CHEMBL5401122 | — | IC50 | = | 8396.0 | nM | 5.08 |
| CHEMBL184238 | URB-597 | IC50 | = | 9384.0 | nM | 5.03 |
| CHEMBL5419246 | — | IC50 | = | 9878.0 | nM | 5.00 |
| CHEMBL5403566 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5396366 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5419776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5436635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5403865 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5430706 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5416058 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5427155 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412058 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5417524 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5440014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5419615 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5405509 | — | IC50 | > | 10000.0 | nM | - |