Assay Detail
Binding
CHEMBL5333702
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Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.44 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650902 | — | — | 1 | 9.30 |
| CHEMBL3769930 | — | — | 1 | 9.13 |
| CHEMBL4650795 | — | — | 1 | 8.89 |
| CHEMBL4650581 | — | — | 1 | 8.68 |
| CHEMBL408867 | [11C]SA4503 | — | 1 | 8.34 |
| CHEMBL4297224 | BLARCAMESINE | 3.0 | 1 | 8.20 |
| CHEMBL4650909 | — | — | 1 | 7.92 |
| CHEMBL596802 | PRIDOPIDINE | 3.0 | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650902 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL3769930 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL4650795 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4650581 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL408867 | [11C]SA4503 | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4297224 | BLARCAMESINE | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4650909 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL596802 | PRIDOPIDINE | Ki | = | 82.0 | nM | 7.09 |