Assay Detail
Binding
CHEMBL5334084
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Binding affinity to human lysosomal acid alpha-glucosidase assessed as inhibition constant incubated for 30 mins by fluorescence based spectrophotometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Pharmacological Chaperone Effects of <i>N</i>-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.36 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 7.23 |
| CHEMBL5422487 | — | — | 1 | 6.14 |
| CHEMBL5437944 | — | — | 1 | 5.85 |
| CHEMBL5429373 | — | — | 1 | 5.85 |
| CHEMBL5398088 | — | — | 1 | 5.66 |
| CHEMBL5432010 | — | — | 1 | 5.24 |
| CHEMBL5410585 | — | — | 1 | 5.15 |
| CHEMBL5418723 | — | — | 1 | 5.07 |
| CHEMBL5417861 | — | — | 1 | 5.00 |
| CHEMBL80254 | — | — | 1 | 4.85 |
| CHEMBL5424528 | — | — | 1 | 4.70 |
| CHEMBL5412126 | — | — | 1 | 4.70 |
| CHEMBL5398090 | — | — | 1 | 4.19 |
| CHEMBL310229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL5422487 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL5437944 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL5429373 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL5398088 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL5432010 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL5410585 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL5418723 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL5417861 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL80254 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL5424528 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL5412126 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL5398090 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL310229 | — | Ki | = | 258000.0 | nM | - |