Assay Detail
Functional
CHEMBL5335288
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Cytotoxicity against human HCT-116 cells incubated for 48 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.14 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415097 | — | — | 1 | 7.47 |
| CHEMBL5412412 | — | — | 1 | 7.37 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 7.26 |
| CHEMBL5440783 | — | — | 1 | 5.49 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.43 |
| CHEMBL5430991 | — | — | 1 | 5.13 |
| CHEMBL5077765 | — | — | 1 | 4.81 |
| CHEMBL245067 | PHLORIZIN | — | 1 | - |
| CHEMBL5440668 | — | — | 1 | - |
| CHEMBL5094407 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415097 | — | IC50 | = | 34.08 | nM | 7.47 |
| CHEMBL5412412 | — | IC50 | = | 42.26 | nM | 7.37 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 54.93 | nM | 7.26 |
| CHEMBL5440783 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL5430991 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL5077765 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL245067 | PHLORIZIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5440668 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5094407 | — | IC50 | > | 100000.0 | nM | - |