Assay Detail
Binding
CHEMBL5336358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-1 MPro
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441971 | — | — | 1 | 6.15 |
| CHEMBL5075209 | — | — | 1 | 6.05 |
| CHEMBL5277714 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441971 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5075209 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5277714 | — | IC50 | = | 2390.0 | nM | 5.62 |