Assay Detail
Binding
CHEMBL5336973
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Displacement of [3H]-LSD from 5-HT6 receptor (unknown origin) assessed as inhibition constant by radioligand binding assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT<sub>6</sub> Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.18 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.15 |
| CHEMBL5419441 | — | — | 1 | 8.10 |
| CHEMBL5405562 | — | — | 1 | 8.05 |
| CHEMBL5436003 | — | — | 1 | 7.85 |
| CHEMBL5406900 | — | — | 1 | 7.68 |
| CHEMBL5410706 | — | — | 1 | 7.68 |
| CHEMBL5405414 | — | — | 1 | 7.66 |
| CHEMBL5434373 | — | — | 1 | 7.48 |
| CHEMBL5416678 | — | — | 1 | 7.44 |
| CHEMBL5402096 | — | — | 1 | 7.34 |
| CHEMBL5420304 | — | — | 1 | 7.28 |
| CHEMBL5398978 | — | — | 1 | 7.16 |
| CHEMBL5407925 | — | — | 1 | 7.12 |
| CHEMBL5400892 | — | — | 1 | 7.10 |
| CHEMBL5395867 | — | — | 1 | 7.10 |
| CHEMBL4462404 | — | — | 1 | 6.96 |
| CHEMBL5433857 | — | — | 1 | 6.91 |
| CHEMBL5423649 | — | — | 1 | 6.78 |
| CHEMBL5406837 | — | — | 1 | 6.71 |
| CHEMBL4580959 | — | — | 1 | 6.62 |
| CHEMBL5397523 | — | — | 1 | 6.56 |
| CHEMBL5433300 | — | — | 1 | 5.99 |
| CHEMBL5397704 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL5419441 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5405562 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL5436003 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL5406900 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5410706 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5405414 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL5434373 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL5416678 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL5402096 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL5420304 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL5398978 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL5407925 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL5400892 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL5395867 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL4462404 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL5433857 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL5423649 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL5406837 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL4580959 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL5397523 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL5433300 | — | Ki | = | 1023.0 | nM | 5.99 |
| CHEMBL5397704 | — | Ki | = | 3065.0 | nM | 5.51 |