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Compound Detail

CHEMBL5397704

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CCC([Se]Cc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1

Basic Information

ChEMBL ID CHEMBL5397704
Phase Preclinical
Structure Type MOL
InChI Key ZDBURNHVADOXDL-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

405.4
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H26N6Se
MW 405.41

Activity Summary

Ki 4 meas. best 5.99

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 2A
CHEMBL224
Ki 5.99 5.99 1022.0 1
5-hydroxytryptamine receptor 1A
CHEMBL214
Ki 5.94 5.94 1149.0 1
5-hydroxytryptamine receptor 6
CHEMBL3371
Ki 5.51 5.51 3065.0 1
5-hydroxytryptamine receptor 7
CHEMBL3155
Ki 5.06 5.06 8752.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
38190615 10.1021/acs.jmedchem.3c02148 Unchecked 3
38190615 10.1021/acs.jmedchem.3c02148 5-hydroxytryptamine receptor 6 2
38190615 10.1021/acs.jmedchem.3c02148 5-hydroxytryptamine receptor 1A 1
38190615 10.1021/acs.jmedchem.3c02148 5-hydroxytryptamine receptor 2A 1
38190615 10.1021/acs.jmedchem.3c02148 5-hydroxytryptamine receptor 7 1

Data from ChEMBL 36 via Core Engine