Assay Detail
Binding
CHEMBL5336974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor (unknown origin) assessed as inhibition constant by radioligand binding assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT<sub>6</sub> Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.57 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.50 |
| CHEMBL5395867 | — | — | 1 | 6.05 |
| CHEMBL5397704 | — | — | 1 | 5.94 |
| CHEMBL5406837 | — | — | 1 | 5.76 |
| CHEMBL5433300 | — | — | 1 | 5.72 |
| CHEMBL5410706 | — | — | 1 | 5.68 |
| CHEMBL5419441 | — | — | 1 | 5.64 |
| CHEMBL5423649 | — | — | 1 | 5.54 |
| CHEMBL5405562 | — | — | 1 | 5.52 |
| CHEMBL5436003 | — | — | 1 | 5.45 |
| CHEMBL5420304 | — | — | 1 | 5.43 |
| CHEMBL5407925 | — | — | 1 | 5.43 |
| CHEMBL5434373 | — | — | 1 | 5.42 |
| CHEMBL5433857 | — | — | 1 | 5.39 |
| CHEMBL5405414 | — | — | 1 | 5.38 |
| CHEMBL5400892 | — | — | 1 | 5.33 |
| CHEMBL5402096 | — | — | 1 | 5.29 |
| CHEMBL4462404 | — | — | 1 | 5.28 |
| CHEMBL5416678 | — | — | 1 | 5.23 |
| CHEMBL5406900 | — | — | 1 | 5.22 |
| CHEMBL4580959 | — | — | 1 | 5.18 |
| CHEMBL5397523 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL5395867 | — | Ki | = | 893.0 | nM | 6.05 |
| CHEMBL5397704 | — | Ki | = | 1149.0 | nM | 5.94 |
| CHEMBL5406837 | — | Ki | = | 1718.0 | nM | 5.76 |
| CHEMBL5433300 | — | Ki | = | 1904.0 | nM | 5.72 |
| CHEMBL5410706 | — | Ki | = | 2070.0 | nM | 5.68 |
| CHEMBL5419441 | — | Ki | = | 2306.0 | nM | 5.64 |
| CHEMBL5423649 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL5405562 | — | Ki | = | 2999.0 | nM | 5.52 |
| CHEMBL5436003 | — | Ki | = | 3533.0 | nM | 5.45 |
| CHEMBL5420304 | — | Ki | = | 3702.0 | nM | 5.43 |
| CHEMBL5407925 | — | Ki | = | 3671.0 | nM | 5.43 |
| CHEMBL5434373 | — | Ki | = | 3812.0 | nM | 5.42 |
| CHEMBL5433857 | — | Ki | = | 4084.0 | nM | 5.39 |
| CHEMBL5405414 | — | Ki | = | 4145.0 | nM | 5.38 |
| CHEMBL5400892 | — | Ki | = | 4645.0 | nM | 5.33 |
| CHEMBL5402096 | — | Ki | = | 5110.0 | nM | 5.29 |
| CHEMBL4462404 | — | Ki | = | 5311.0 | nM | 5.28 |
| CHEMBL5416678 | — | Ki | = | 5948.0 | nM | 5.23 |
| CHEMBL5406900 | — | Ki | = | 6071.0 | nM | 5.22 |
| CHEMBL4580959 | — | Ki | = | 6647.0 | nM | 5.18 |
| CHEMBL5397523 | — | Ki | = | 7614.0 | nM | 5.12 |