Compound Detail
CHEMBL5410706
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Basic Information
| ChEMBL ID | CHEMBL5410706 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YZNGYGWNHBTIFR-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
457.8
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 7.68 | 7.68 | 21.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.51 | 6.51 | 306.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 5.68 | 5.68 | 2070.0 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 5.4 | 5.4 | 4006.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 21.0 | nM | 7.68 | Displacement of [3H]-LSD from 5-HT6 receptor (unknown origin) assessed as inhibi... | 38190615 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 306.0 | nM | 6.51 | Displacement of [3H]-Ketanserin from 5-HT2A receptor (unknown origin) assessed a... | 38190615 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 2070.0 | nM | 5.68 | Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor (unknown origin) assessed as... | 38190615 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 4006.0 | nM | 5.4 | Displacement of [3H]-5-CT from 5-HT7 receptor (unknown origin) assessed as inhib... | 38190615 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38190615 | 10.1021/acs.jmedchem.3c02148 | Unchecked | 3 |
| 38190615 | 10.1021/acs.jmedchem.3c02148 | 5-hydroxytryptamine receptor 6 | 2 |
| 38190615 | 10.1021/acs.jmedchem.3c02148 | 5-hydroxytryptamine receptor 1A | 1 |
| 38190615 | 10.1021/acs.jmedchem.3c02148 | 5-hydroxytryptamine receptor 2A | 1 |
| 38190615 | 10.1021/acs.jmedchem.3c02148 | 5-hydroxytryptamine receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine