Assay Detail
Functional
CHEMBL5337178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei assessed as inhibition of parasite growth incubated for 72 hrs by resazurin reagent fluorimetric analysis
22
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.35 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5409850 | — | — | 1 | 8.00 |
| CHEMBL5432114 | — | — | 1 | 7.80 |
| CHEMBL5422988 | — | — | 1 | 7.40 |
| CHEMBL5417746 | — | — | 1 | 7.30 |
| CHEMBL5411692 | — | — | 1 | 7.20 |
| CHEMBL5411418 | — | — | 1 | 7.10 |
| CHEMBL5440925 | — | — | 1 | 6.80 |
| CHEMBL5428744 | — | — | 1 | 6.60 |
| CHEMBL5414294 | — | — | 1 | 6.40 |
| CHEMBL5428468 | — | — | 2 | 6.20 |
| CHEMBL5433039 | — | — | 1 | 5.80 |
| CHEMBL5413276 | — | — | 2 | 5.50 |
| CHEMBL5438730 | — | — | 1 | 5.20 |
| CHEMBL5399254 | — | — | 1 | 4.60 |
| CHEMBL4568326 | — | — | 1 | 4.50 |
| CHEMBL5413625 | — | — | 1 | - |
| CHEMBL5412074 | — | — | 1 | - |
| CHEMBL5440199 | — | — | 1 | - |
| CHEMBL5429276 | — | — | 1 | - |
| CHEMBL5420989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5409850 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5432114 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5422988 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5417746 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5411692 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5411418 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5440925 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5428744 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5414294 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5428468 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5428468 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5433039 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL5413276 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL5413276 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5438730 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL5399254 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4568326 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL5413625 | — | IC50 | > | 63095.73 | nM | - |
| CHEMBL5412074 | — | IC50 | > | 63095.73 | nM | - |
| CHEMBL5440199 | — | IC50 | > | 63095.73 | nM | - |
| CHEMBL5429276 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5420989 | — | IC50 | > | 10000.0 | nM | - |