Assay Detail
Binding
CHEMBL5339634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from human sigma 1 receptor transfected in HEK293 cells assessed as inhibition constant by competition binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting σ<sub>2</sub>R/TMEM97 with novel aminotetralins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.84 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403404 | — | — | 1 | 7.09 |
| CHEMBL5439058 | — | — | 1 | 6.73 |
| CHEMBL5421620 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403404 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL5439058 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL5421620 | — | Ki | = | 196.0 | nM | 6.71 |