Assay Detail
Binding
CHEMBL5339817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system using synthetic RNA 5'P-uacacucgaucuggacuaaagcugcuc-3' and SAM as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by RF/MS analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.02 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396973 | — | — | 1 | 8.44 |
| CHEMBL5405105 | — | — | 1 | 8.36 |
| CHEMBL5082807 | — | — | 1 | 8.21 |
| CHEMBL5417468 | — | — | 1 | 8.21 |
| CHEMBL5410561 | — | — | 1 | 8.21 |
| CHEMBL5398269 | — | — | 1 | 8.21 |
| CHEMBL5415737 | — | — | 1 | 8.21 |
| CHEMBL5075067 | — | — | 1 | 8.21 |
| CHEMBL5080742 | — | — | 1 | 8.21 |
| CHEMBL5091295 | — | — | 1 | 8.21 |
| CHEMBL5092868 | — | — | 1 | 8.21 |
| CHEMBL5083389 | — | — | 1 | 8.21 |
| CHEMBL5418009 | — | — | 1 | 8.21 |
| CHEMBL5423125 | — | — | 1 | 8.21 |
| CHEMBL5405396 | — | — | 1 | 8.21 |
| CHEMBL5405801 | — | — | 1 | 8.21 |
| CHEMBL5419185 | — | — | 1 | 8.21 |
| CHEMBL5402970 | — | — | 1 | 8.10 |
| CHEMBL5288865 | — | — | 1 | 4.29 |
| CHEMBL5411328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396973 | — | IC50 | = | 3.63 | nM | 8.44 |
| CHEMBL5405105 | — | IC50 | = | 4.35 | nM | 8.36 |
| CHEMBL5082807 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5417468 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5410561 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5398269 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5415737 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5075067 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5080742 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5091295 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5092868 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5083389 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5418009 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5423125 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5405396 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5405801 | — | IC50 | = | 6.22 | nM | 8.21 |
| CHEMBL5419185 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5402970 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5288865 | — | IC50 | = | 51700.0 | nM | 4.29 |
| CHEMBL5411328 | — | IC50 | < | 6.0 | nM | - |