Compound Detail
CHEMBL5288865
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5288865 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | REAFJZKIZSICLE-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
2.85
ALogP
4
HBA
1
HBD
79.6
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| METTL3/METTL14 CHEMBL4106140 | IC50 | 4.29 | 4.29 | 51700.0 | 1 |
| N6-adenosine-methyltransferase catalytic subunit CHEMBL4739695 | IC50 | 4.29 | 4.29 | 51700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N6-adenosine-methyltransferase catalytic subunit | IC50 | = | 51700.0 | nM | 4.29 | Inhibition of METTL3 (unknown origin) | 35063732 |
| METTL3/METTL14 | IC50 | = | 51700.0 | nM | 4.29 | Inhibition of full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unk... | 36692498 |
| N6-adenosine-methyltransferase catalytic subunit | IC50 | = | 51700.0 | nM | 4.29 | Inhibition of full length His-tagged METTL3 (unknown origin) expressed in Sf9 ce... | 38805939 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35063732 | 10.1016/j.ejmech.2022.114118 | N6-adenosine-methyltransferase catalytic subunit | 1 |
| 36692498 | 10.1021/acs.jmedchem.2c01601 | METTL3/METTL14 | 1 |
| 38805939 | 10.1016/j.ejmech.2024.116526 | N6-adenosine-methyltransferase catalytic subunit | 1 |
Data from ChEMBL 36 via Core Engine