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Assay Detail

CHEMBL5340517

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type NCM460
Confidence 1 — Organism
Curated By Autocuration

Target

NCM460 (CHEMBL4483264)
Type CELL-LINE
Organism Homo sapiens

Publication

Development and Characterization of Benzoselenazole Derivatives as Potent and Selective <i>c-MYC</i> Transcription Inhibitors.
Wu TY, Chen XC, Tang GX, Shao W, Li ZC, Chen SB, Huang ZS, Tan JH.
J Med Chem (2023) 66 : 5484 -5499
PubMed 37036951 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.38 4.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5438961 1 4.58
CHEMBL5433462 1 4.54
CHEMBL5403739 1 4.52
CHEMBL5441075 1 4.45
CHEMBL5438257 1 4.41
CHEMBL5416924 1 4.37
CHEMBL5401465 1 4.34
CHEMBL5428440 1 4.11
CHEMBL5408674 1 4.06
CHEMBL5436315 1 -
CHEMBL5412161 1 -
CHEMBL5435283 1 -
CHEMBL5413669 1 -
CHEMBL5412368 1 -
CHEMBL5417204 1 -
CHEMBL5401110 1 -
CHEMBL5397977 1 -
CHEMBL5439102 1 -
CHEMBL5413142 1 -
CHEMBL5409927 1 -
CHEMBL5429301 1 -
CHEMBL5438771 1 -
CHEMBL5404848 1 -
CHEMBL5426320 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5438961 IC50 = 26100.0 nM 4.58
CHEMBL5433462 IC50 = 29200.0 nM 4.54
CHEMBL5403739 IC50 = 30200.0 nM 4.52
CHEMBL5441075 IC50 = 35600.0 nM 4.45
CHEMBL5438257 IC50 = 39300.0 nM 4.41
CHEMBL5416924 IC50 = 42500.0 nM 4.37
CHEMBL5401465 IC50 = 45600.0 nM 4.34
CHEMBL5428440 IC50 = 77600.0 nM 4.11
CHEMBL5408674 IC50 = 87700.0 nM 4.06
CHEMBL5436315 IC50 > 100000.0 nM -
CHEMBL5412161 IC50 > 100000.0 nM -
CHEMBL5435283 IC50 > 100000.0 nM -
CHEMBL5413669 IC50 > 100000.0 nM -
CHEMBL5412368 IC50 > 100000.0 nM -
CHEMBL5417204 IC50 > 100000.0 nM -
CHEMBL5401110 IC50 > 100000.0 nM -
CHEMBL5397977 IC50 > 100000.0 nM -
CHEMBL5439102 IC50 > 100000.0 nM -
CHEMBL5413142 IC50 > 100000.0 nM -
CHEMBL5409927 IC50 > 100000.0 nM -
CHEMBL5429301 IC50 > 100000.0 nM -
CHEMBL5438771 IC50 > 100000.0 nM -
CHEMBL5404848 IC50 > 100000.0 nM -
CHEMBL5426320 IC50 > 100000.0 nM -