Assay Detail
Functional
CHEMBL5341334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring A17 mutant infected in human TZM-bl cells
18
Total Activities
17
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
<i>N</i>-Phenyl-1-(phenylsulfonyl)-1<i>H</i>-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.27 | 9.16 |
| IC50 | 4 | 8.54 | 9.10 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397495 | — | — | 2 | 9.16 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.10 |
| CHEMBL5395699 | — | — | 1 | 8.89 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.75 |
| CHEMBL5439006 | — | — | 1 | 7.61 |
| CHEMBL5417242 | — | — | 1 | 7.40 |
| CHEMBL5412528 | — | — | 1 | 7.26 |
| CHEMBL5439895 | — | — | 1 | 6.82 |
| CHEMBL5430523 | — | — | 1 | 6.76 |
| CHEMBL5424813 | — | — | 1 | 6.51 |
| CHEMBL5426382 | — | — | 1 | 6.15 |
| CHEMBL5432903 | — | — | 1 | - |
| CHEMBL5408046 | — | — | 1 | - |
| CHEMBL5407783 | — | — | 1 | - |
| CHEMBL5402762 | — | — | 1 | - |
| CHEMBL5432006 | — | — | 1 | - |
| CHEMBL5411690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397495 | — | EC50 | = | 0.689 | nM | 9.16 |
| CHEMBL175691 | RILPIVIRINE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5395699 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5397495 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5439006 | — | EC50 | = | 24.5 | nM | 7.61 |
| CHEMBL5417242 | — | EC50 | = | 39.6 | nM | 7.40 |
| CHEMBL5412528 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5439895 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5430523 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5424813 | — | EC50 | = | 306.0 | nM | 6.51 |
| CHEMBL5426382 | — | EC50 | = | 705.0 | nM | 6.15 |
| CHEMBL5402762 | — | Activity | - | — | - | |
| CHEMBL5408046 | — | Activity | - | — | - | |
| CHEMBL5407783 | — | Activity | - | — | - | |
| CHEMBL5432903 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5432006 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5411690 | — | EC50 | > | 1000.0 | nM | - |