Assay Detail
Functional
CHEMBL5341337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring K103N mutant infected in human TZM-bl cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
<i>N</i>-Phenyl-1-(phenylsulfonyl)-1<i>H</i>-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.35 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 8.89 |
| CHEMBL5397495 | — | — | 1 | 8.23 |
| CHEMBL5395699 | — | — | 1 | 8.23 |
| CHEMBL5412528 | — | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5397495 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5395699 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5412528 | — | IC50 | = | 8.8 | nM | 8.06 |