Assay Detail
Functional
CHEMBL5341353
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV IIIB infected in human TZM-bl cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
<i>N</i>-Phenyl-1-(phenylsulfonyl)-1<i>H</i>-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.19 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397495 | — | — | 1 | 9.51 |
| CHEMBL5412528 | — | — | 1 | 9.49 |
| CHEMBL5395699 | — | — | 1 | 9.49 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.46 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.18 |
| CHEMBL5410709 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397495 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL5412528 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5395699 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL175691 | RILPIVIRINE | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL5410709 | — | IC50 | = | 9.3 | nM | 8.03 |