Assay Detail
Binding
CHEMBL5342462
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSF1R (unknown origin) in presence of ATP by Z-LYTE based FRET assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Development of Highly Selective Pyrrolo[2,3-<i>d</i>]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.82 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5439126 | — | — | 1 | 9.52 |
| CHEMBL5425883 | — | — | 1 | 9.40 |
| CHEMBL5411617 | — | — | 1 | 9.40 |
| CHEMBL5405206 | — | — | 1 | 9.40 |
| CHEMBL5430348 | — | — | 1 | 9.40 |
| CHEMBL5406924 | — | — | 1 | 9.30 |
| CHEMBL5404033 | — | — | 1 | 9.22 |
| CHEMBL5436321 | — | — | 1 | 9.05 |
| CHEMBL5397490 | — | — | 1 | 8.85 |
| CHEMBL5435513 | — | — | 1 | 8.85 |
| CHEMBL5398778 | — | — | 1 | 8.74 |
| CHEMBL5420485 | — | — | 1 | 8.57 |
| CHEMBL5397426 | — | — | 1 | 8.52 |
| CHEMBL5416772 | — | — | 1 | 8.40 |
| CHEMBL5417719 | — | — | 1 | 8.31 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 8.30 |
| CHEMBL5415647 | — | — | 1 | 8.19 |
| CHEMBL5416379 | — | — | 1 | 8.11 |
| CHEMBL5431035 | — | — | 1 | 7.96 |
| CHEMBL5418087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5439126 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5425883 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5411617 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5405206 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5430348 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5406924 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5404033 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5436321 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5397490 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5435513 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5398778 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5420485 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5397426 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5416772 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5417719 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5415647 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5416379 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL5431035 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5418087 | — | IC50 | < | 0.3 | nM | - |