Compound Detail
CHEMBL5411617
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5411617 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HNJOCLQAHHIZPS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
407.5
MW (Da)
3.22
ALogP
5
HBA
2
HBD
105.0
PSA (Ų)
0.53
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 9.4 | 9.4 | 0.4 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.01 | 7.01 | 98.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.4 | nM | 9.4 | Inhibition of CSF1R (unknown origin) in presence of ATP by Z-LYTE based FRET ass... | 37191268 |
| Epidermal growth factor receptor | IC50 | = | 98.0 | nM | 7.01 | Inhibition of EGFR (unknown origin) in presence of ATP by Z-LYTE based FRET assa... | 37191268 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37191268 | 10.1021/acs.jmedchem.3c00428 | Macrophage colony-stimulating factor 1 receptor | 3 |
| 37191268 | 10.1021/acs.jmedchem.3c00428 | Epidermal growth factor receptor | 1 |
| 38141285 | 10.1016/j.ejmech.2023.116053 | No relevant target | 1 |
| 38141285 | 10.1016/j.ejmech.2023.116053 | BaF3 | 1 |
Data from ChEMBL 36 via Core Engine