Assay Detail
Binding
CHEMBL5342465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin) in presence of ATP by Z-LYTE based FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Development of Highly Selective Pyrrolo[2,3-<i>d</i>]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.89 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5418087 | — | — | 1 | 7.52 |
| CHEMBL5439126 | — | — | 1 | 7.28 |
| CHEMBL5411617 | — | — | 1 | 7.01 |
| CHEMBL5406924 | — | — | 1 | 6.93 |
| CHEMBL5425883 | — | — | 1 | 6.93 |
| CHEMBL5404033 | — | — | 1 | 6.90 |
| CHEMBL5436321 | — | — | 1 | 6.38 |
| CHEMBL5397490 | — | — | 1 | 6.13 |
| CHEMBL5398778 | — | — | 1 | - |
| CHEMBL5420485 | — | — | 1 | - |
| CHEMBL5397426 | — | — | 1 | - |
| CHEMBL5415647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5418087 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5439126 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5411617 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5406924 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5425883 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL5404033 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5436321 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL5397490 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL5398778 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5420485 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5397426 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5415647 | — | IC50 | > | 1000.0 | nM | - |