Assay Detail
Binding
CHEMBL5342463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSF1R (unknown origin) using ultra ULight GT peptide as substrate incubated for 1 hr in presence of 25 uM of ATP by LANCE Ultra TR-FRET assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Development of Highly Selective Pyrrolo[2,3-<i>d</i>]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.33 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397490 | — | — | 1 | 8.00 |
| CHEMBL5435513 | — | — | 1 | 7.75 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 7.70 |
| CHEMBL5397426 | — | — | 1 | 7.54 |
| CHEMBL5415647 | — | — | 1 | 7.52 |
| CHEMBL5416379 | — | — | 1 | 6.98 |
| CHEMBL5416772 | — | — | 1 | 6.60 |
| CHEMBL5417719 | — | — | 1 | 6.56 |
| CHEMBL5406924 | — | — | 1 | - |
| CHEMBL5398778 | — | — | 1 | - |
| CHEMBL5420485 | — | — | 1 | - |
| CHEMBL5436321 | — | — | 1 | - |
| CHEMBL5425883 | — | — | 1 | - |
| CHEMBL5431035 | — | — | 1 | - |
| CHEMBL5439126 | — | — | 1 | - |
| CHEMBL5405206 | — | — | 1 | - |
| CHEMBL5418087 | — | — | 1 | - |
| CHEMBL5430348 | — | — | 1 | - |
| CHEMBL5411617 | — | — | 1 | - |
| CHEMBL5404033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397490 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5435513 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5397426 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5415647 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5416379 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5416772 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL5417719 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL5406924 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5398778 | — | IC50 | - | — | - | |
| CHEMBL5420485 | — | IC50 | - | — | - | |
| CHEMBL5436321 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5425883 | — | IC50 | - | — | - | |
| CHEMBL5431035 | — | IC50 | - | — | - | |
| CHEMBL5439126 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5405206 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5418087 | — | IC50 | - | — | - | |
| CHEMBL5430348 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5411617 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5404033 | — | IC50 | < | 3.0 | nM | - |