Assay Detail
Functional
CHEMBL5344394
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Cytotoxicity against human IGROV-1 cells assessed as inhibition of cell growth incubated for 5 days by CellTiter-Glo luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships of Bis-Intercalating Peptides and Their Application as Antibody-Drug Conjugate Payloads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.33 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5429643 | — | — | 1 | 8.92 |
| CHEMBL441158 | — | — | 1 | 8.80 |
| CHEMBL5407380 | — | — | 1 | 8.19 |
| CHEMBL5410782 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5429643 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL441158 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5407380 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5410782 | — | IC50 | = | 39.0 | nM | 7.41 |