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Assay Detail

CHEMBL5345461

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Functional
Antiviral activity against HIV2 ROD infected in human MT4 cells assessed as reduction in virus induced cytopathic effect measured after 5 days by MTT assay
ChEMBL ↗
105
Total Activities
105
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 2
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 2 (CHEMBL380) ↗
Type ORGANISM
Organism Human immunodeficiency virus 2

Publication

Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
Xu S, Sun L, Barnett M, Zhang X, Ding D, Gattu A, Shi D, Taka JRH, Shen W, Jiang X, Cocklin S, De Clercq E, Pannecouque C, Goldstone DC, Liu X, Dick A, Zhan P.
J Med Chem (2023) 66 : 16303 -16329
PubMed 38054267 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 105 5.56 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4471665 — — 1 7.52
CHEMBL5395574 — — 1 7.10
CHEMBL5422125 — — 1 7.10
CHEMBL5410694 — — 1 7.00
CHEMBL5419397 — — 1 7.00
CHEMBL5438195 — — 1 7.00
CHEMBL5422296 — — 1 6.92
CHEMBL5404817 — — 1 6.82
CHEMBL5413331 — — 1 6.82
CHEMBL5438769 — — 1 6.82
CHEMBL5397096 — — 1 6.75
CHEMBL5412713 — — 1 6.50
CHEMBL5420176 — — 1 6.46
CHEMBL5408443 — — 1 6.46
CHEMBL5407073 — — 1 6.44
CHEMBL5404188 — — 1 6.43
CHEMBL5432541 — — 1 6.40
CHEMBL5426569 — — 1 6.39
CHEMBL5415995 — — 1 6.39
CHEMBL5439879 — — 1 6.38
CHEMBL5408392 — — 1 6.27
CHEMBL5396508 — — 1 6.25
CHEMBL5412661 — — 1 6.24
CHEMBL5395227 — — 1 6.23
CHEMBL5424603 — — 1 6.22
CHEMBL5412080 — — 1 6.14
CHEMBL5438239 — — 1 5.71
CHEMBL4788393 — — 1 5.65
CHEMBL5402412 — — 1 5.64
CHEMBL5405399 — — 1 5.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4471665 — EC50 = 30.0 nM 7.52
CHEMBL5395574 — EC50 = 80.0 nM 7.10
CHEMBL5422125 — EC50 = 80.0 nM 7.10
CHEMBL5410694 — EC50 = 100.0 nM 7.00
CHEMBL5419397 — EC50 = 100.0 nM 7.00
CHEMBL5438195 — EC50 = 100.0 nM 7.00
CHEMBL5422296 — EC50 = 120.0 nM 6.92
CHEMBL5404817 — EC50 = 150.0 nM 6.82
CHEMBL5413331 — EC50 = 150.0 nM 6.82
CHEMBL5438769 — EC50 = 150.0 nM 6.82
CHEMBL5397096 — EC50 = 180.0 nM 6.75
CHEMBL5412713 — EC50 = 320.0 nM 6.50
CHEMBL5420176 — EC50 = 350.0 nM 6.46
CHEMBL5408443 — EC50 = 350.0 nM 6.46
CHEMBL5407073 — EC50 = 360.0 nM 6.44
CHEMBL5404188 — EC50 = 370.0 nM 6.43
CHEMBL5432541 — EC50 = 400.0 nM 6.40
CHEMBL5426569 — EC50 = 410.0 nM 6.39
CHEMBL5415995 — EC50 = 410.0 nM 6.39
CHEMBL5439879 — EC50 = 420.0 nM 6.38
CHEMBL5408392 — EC50 = 540.0 nM 6.27
CHEMBL5396508 — EC50 = 560.0 nM 6.25
CHEMBL5412661 — EC50 = 570.0 nM 6.24
CHEMBL5395227 — EC50 = 590.0 nM 6.23
CHEMBL5424603 — EC50 = 600.0 nM 6.22
CHEMBL5412080 — EC50 = 730.0 nM 6.14
CHEMBL5438239 — EC50 = 1970.0 nM 5.71
CHEMBL4788393 — EC50 = 2220.0 nM 5.65
CHEMBL5402412 — EC50 = 2300.0 nM 5.64
CHEMBL5405399 — EC50 = 2690.0 nM 5.57
CHEMBL5398670 — EC50 = 3420.0 nM 5.47
CHEMBL5434305 — EC50 = 3740.0 nM 5.43
CHEMBL5402361 — EC50 = 3730.0 nM 5.43
CHEMBL5434657 — EC50 = 3940.0 nM 5.41
CHEMBL5439483 — EC50 = 3980.0 nM 5.40
CHEMBL5418914 — EC50 = 4070.0 nM 5.39
CHEMBL5413629 — EC50 = 4160.0 nM 5.38
CHEMBL5409979 — EC50 = 4270.0 nM 5.37
CHEMBL5399060 — EC50 = 4520.0 nM 5.34
CHEMBL5433441 — EC50 = 4890.0 nM 5.31
CHEMBL5408073 — EC50 = 4860.0 nM 5.31
CHEMBL5394018 — EC50 = 4980.0 nM 5.30
CHEMBL5431903 — EC50 = 5070.0 nM 5.29
CHEMBL5439434 — EC50 = 5810.0 nM 5.24
CHEMBL5423814 — EC50 = 5870.0 nM 5.23
CHEMBL5400680 — EC50 = 6520.0 nM 5.19
CHEMBL5411600 — EC50 = 6590.0 nM 5.18
CHEMBL5402243 — EC50 = 6650.0 nM 5.18
CHEMBL5430540 — EC50 = 6590.0 nM 5.18
CHEMBL5433915 — EC50 = 6800.0 nM 5.17