Assay Detail
Functional
CHEMBL5345502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 IIIB infected in human MT4 cells assessed as protection against virus induced cytopathic effect
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.32 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410423 | — | — | 1 | 6.92 |
| CHEMBL5415284 | — | — | 1 | 6.80 |
| CHEMBL5439668 | — | — | 1 | 6.75 |
| CHEMBL5428349 | — | — | 1 | 6.70 |
| CHEMBL5413937 | — | — | 1 | 6.68 |
| CHEMBL4471665 | — | — | 1 | 6.68 |
| CHEMBL5419705 | — | — | 1 | 6.62 |
| CHEMBL5435741 | — | — | 1 | 6.28 |
| CHEMBL4788393 | — | — | 1 | 6.12 |
| CHEMBL5411657 | — | — | 1 | 6.10 |
| CHEMBL5414633 | — | — | 1 | 6.07 |
| CHEMBL5437047 | — | — | 1 | 6.04 |
| CHEMBL5423114 | — | — | 1 | 6.03 |
| CHEMBL5427261 | — | — | 1 | 6.00 |
| CHEMBL5417559 | — | — | 1 | 5.83 |
| CHEMBL5420974 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410423 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5415284 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5439668 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5428349 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5413937 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4471665 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5419705 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5435741 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4788393 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5411657 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5414633 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5437047 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5423114 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5427261 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5417559 | — | EC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL5420974 | — | EC50 | = | 2840.0 | nM | 5.55 |