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Assay Detail

CHEMBL5345503

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV-2 ROD infected in human MT4 cells assessed as protection against virus induced cytopathic effect
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 2
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 2 (CHEMBL380)
Type ORGANISM
Organism Human immunodeficiency virus 2

Publication

Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
Xu S, Sun L, Barnett M, Zhang X, Ding D, Gattu A, Shi D, Taka JRH, Shen W, Jiang X, Cocklin S, De Clercq E, Pannecouque C, Goldstone DC, Liu X, Dick A, Zhan P.
J Med Chem (2023) 66 : 16303 -16329
PubMed 38054267 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 6.73 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5413937 1 7.52
CHEMBL4471665 1 7.52
CHEMBL5410423 1 7.30
CHEMBL5439668 1 7.05
CHEMBL5428349 1 7.00
CHEMBL5415284 1 6.96
CHEMBL5419705 1 6.92
CHEMBL5437047 1 6.92
CHEMBL5435741 1 6.85
CHEMBL5417559 1 6.77
CHEMBL5414633 1 6.46
CHEMBL5411657 1 6.44
CHEMBL5423114 1 6.36
CHEMBL5427261 1 6.32
CHEMBL5420974 1 5.92
CHEMBL4788393 1 5.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5413937 EC50 = 30.0 nM 7.52
CHEMBL4471665 EC50 = 30.0 nM 7.52
CHEMBL5410423 EC50 = 50.0 nM 7.30
CHEMBL5439668 EC50 = 90.0 nM 7.05
CHEMBL5428349 EC50 = 100.0 nM 7.00
CHEMBL5415284 EC50 = 110.0 nM 6.96
CHEMBL5419705 EC50 = 120.0 nM 6.92
CHEMBL5437047 EC50 = 120.0 nM 6.92
CHEMBL5435741 EC50 = 140.0 nM 6.85
CHEMBL5417559 EC50 = 170.0 nM 6.77
CHEMBL5414633 EC50 = 350.0 nM 6.46
CHEMBL5411657 EC50 = 360.0 nM 6.44
CHEMBL5423114 EC50 = 440.0 nM 6.36
CHEMBL5427261 EC50 = 480.0 nM 6.32
CHEMBL5420974 EC50 = 1190.0 nM 5.92
CHEMBL4788393 EC50 = 4160.0 nM 5.38