Assay Detail
Functional
CHEMBL5349941
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Antiviral activity against Vaccinia virus infected in African green monkey Vero cells assessed as reduction virus induced cytopathic effect incubated for 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An Overview of Antivirals against Monkeypox Virus and Other Orthopoxviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.24 | 6.70 |
| IC50 | 3 | 6.25 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420702 | — | — | 1 | 7.00 |
| CHEMBL206291 | — | — | 1 | 6.70 |
| CHEMBL5429031 | — | — | 1 | 6.52 |
| CHEMBL5438900 | — | — | 1 | 5.96 |
| CHEMBL5439471 | — | — | 1 | 5.42 |
| CHEMBL5424359 | — | — | 1 | 5.23 |
| CHEMBL1416460 | — | — | 1 | 4.71 |
| CHEMBL152 | CIDOFOVIR ANHYDROUS | 4.0 | 1 | 4.33 |
| CHEMBL5405806 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420702 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL206291 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5429031 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5438900 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5439471 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5424359 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1416460 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL152 | CIDOFOVIR ANHYDROUS | EC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL5405806 | — | EC50 | = | 50600.0 | nM | 4.30 |