Assay Detail
Functional
CHEMBL5350294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against 1-(4-Amino-2-((3,4-difluorophenyl)amino)thiazol-5-yl)-3-hydroxy-3-methylbutan-1-one-resistant wild type Tb927.8.6290 overexpressing Trypanosoma brucei in presence of 5% Co2 at incubated for 24 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.59 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399411 | — | — | 1 | 6.77 |
| CHEMBL5430949 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399411 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5430949 | — | EC50 | = | 400.0 | nM | 6.40 |