Assay Detail
Binding
CHEMBL5350398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ERalpha degradation (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.54 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076124 | LSZ-102 | 1.0 | 1 | 9.70 |
| CHEMBL4101673 | — | — | 1 | 8.40 |
| CHEMBL4102815 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076124 | LSZ-102 | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4101673 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4102815 | — | EC50 | = | 31.0 | nM | 7.51 |