Compound Detail
CHEMBL4076124
LSZ-102 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL4076124 |
| Name | LSZ-102 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | SJXNPGGVGZXKKI-NYYWCZLTSA-N |
2
Targets
7
Activities
2
Assay Types
13
PK Parameters
6
Publications
2
Known Names
1
Indications
Molecular Properties
470.5
MW (Da)
7.41
ALogP
4
HBA
2
HBD
66.8
PSA (Ų)
0.29
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Breast Neoplasms
Activity Summary
IC50 6 meas. best 9.7
EC50 1 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Estrogen receptor CHEMBL206 | EC50 | 9.7 | 9.7 | 0.2 | 1 |
| Estrogen receptor CHEMBL206 | IC50 | 9.7 | 8.776 | 0.2 | 5 |
| MCF7 CHEMBL387 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 1519.62 | ng.hr.mL-1 | Mus musculus |
| AUC | 4528.27 | ng.hr.mL-1 | Canis lupus familiaris |
| CL | 19.0 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 28.0 | mL.min-1.kg-1 | Mus musculus |
| CL | 5.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 15.0 | % | Canis lupus familiaris |
| Cmax | 492.0 | nM | Mus musculus |
| Cmax | 1068.0 | nM | Mus musculus |
| F | 12.0 | % | Mus musculus |
| F | 33.0 | % | Rattus norvegicus |
| F | 12.0 | % | Canis lupus familiaris |
| T1/2 | 1.4 | hr | Rattus norvegicus |
| T1/2 | 4.1 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Estrogen receptor | EC50 | = | 0.2 | nM | 9.7 | Induction of ERalpha degradation (unknown origin) | 37377342 |
| Estrogen receptor | IC50 | = | 0.2 | nM | 9.7 | Induction of selective estrogen receptor alpha degradation in human MCF7 cells a... | 29562737 |
| Estrogen receptor | IC50 | = | 0.2 | nM | 9.7 | ERalpha Degradation (MCF7 Cells): Plate MCF7 cells at 0.3 million cells/mL (100 ... | - |
| MCF7 | IC50 | = | 1.7 | nM | 8.77 | Antiproliferative activity against human MCF7 cells after 6 days in presence of ... | 29562737 |
| Estrogen receptor | IC50 | = | 6.0 | nM | 8.22 | Induction of selective estrogen receptor alpha degradation in human MCF7 cells h... | 29562737 |
| Estrogen receptor | IC50 | = | 6.1 | nM | 8.21 | ER Transcription Assay (MCF7 Cells): The ER transcription assay is a reporter as... | - |
| Estrogen receptor | IC50 | = | 8.9 | nM | 8.05 | Induction of selective estrogen receptor alpha degradation in human MCF7 cells h... | 29562737 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29562737 | 10.1021/acs.jmedchem.7b01682 | Rattus norvegicus | 13 |
| 29562737 | 10.1021/acs.jmedchem.7b01682 | Canis familiaris | 11 |
| 29562737 | 10.1021/acs.jmedchem.7b01682 | Mus musculus | 7 |
| 29562737 | 10.1021/acs.jmedchem.7b01682 | Estrogen receptor | 6 |
| 29562737 | 10.1021/acs.jmedchem.7b01682 | MCF7 | 2 |
| 37377342 | 10.1021/acs.jmedchem.3c00136 | Estrogen receptor | 1 |
Data from ChEMBL 36 via Core Engine