Assay Detail
Functional
CHEMBL5355407
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KMS-12-PE cells assessed as inhibition of cell proliferation incubated for 48 hrs by CellTiter Glo luminescence based MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KMS-12-PE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.79 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404837 | — | — | 1 | 5.29 |
| CHEMBL5418383 | — | — | 1 | 5.23 |
| CHEMBL5397775 | — | — | 1 | 5.23 |
| CHEMBL5416620 | — | — | 1 | 5.22 |
| CHEMBL5429778 | — | — | 1 | 5.21 |
| CHEMBL5422899 | — | — | 1 | 5.19 |
| CHEMBL5418463 | — | — | 1 | 4.89 |
| CHEMBL5435385 | — | — | 1 | 4.88 |
| CHEMBL5439702 | — | — | 1 | 4.88 |
| CHEMBL5409302 | — | — | 1 | 4.87 |
| CHEMBL5418739 | — | — | 1 | 4.79 |
| CHEMBL5419971 | — | — | 1 | 4.64 |
| CHEMBL5413552 | — | — | 1 | 4.53 |
| CHEMBL5413097 | — | — | 1 | 4.49 |
| CHEMBL5428083 | — | — | 1 | 4.44 |
| CHEMBL5398118 | — | — | 1 | 4.43 |
| CHEMBL5436049 | — | — | 1 | 4.43 |
| CHEMBL5404825 | — | — | 1 | 4.41 |
| CHEMBL5406302 | — | — | 1 | 4.40 |
| CHEMBL5408086 | — | — | 1 | 4.34 |
| CHEMBL5411137 | — | — | 1 | - |
| CHEMBL5436622 | — | — | 1 | - |
| CHEMBL5434742 | — | — | 1 | - |
| CHEMBL5419709 | — | — | 1 | - |
| CHEMBL5406576 | — | — | 1 | - |
| CHEMBL5424693 | — | — | 1 | - |
| CHEMBL5435212 | — | — | 1 | - |
| CHEMBL5397580 | — | — | 1 | - |
| CHEMBL5418032 | — | — | 1 | - |
| CHEMBL5402303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404837 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL5418383 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL5397775 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5416620 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5429778 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL5422899 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL5418463 | — | IC50 | = | 12870.0 | nM | 4.89 |
| CHEMBL5435385 | — | IC50 | = | 13310.0 | nM | 4.88 |
| CHEMBL5439702 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL5409302 | — | IC50 | = | 13610.0 | nM | 4.87 |
| CHEMBL5418739 | — | IC50 | = | 16210.0 | nM | 4.79 |
| CHEMBL5419971 | — | IC50 | = | 23050.0 | nM | 4.64 |
| CHEMBL5413552 | — | IC50 | = | 29820.0 | nM | 4.53 |
| CHEMBL5413097 | — | IC50 | = | 32650.0 | nM | 4.49 |
| CHEMBL5428083 | — | IC50 | = | 36350.0 | nM | 4.44 |
| CHEMBL5436049 | — | IC50 | = | 36790.0 | nM | 4.43 |
| CHEMBL5398118 | — | IC50 | = | 36710.0 | nM | 4.43 |
| CHEMBL5404825 | — | IC50 | = | 38520.0 | nM | 4.41 |
| CHEMBL5406302 | — | IC50 | = | 39990.0 | nM | 4.40 |
| CHEMBL5408086 | — | IC50 | = | 45520.0 | nM | 4.34 |
| CHEMBL468 | THALIDOMIDE | IC50 | > | 75000.0 | nM | - |
| CHEMBL5420053 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5435497 | — | IC50 | - | — | - | |
| CHEMBL5402303 | — | IC50 | - | — | - | |
| CHEMBL5418032 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5397580 | — | IC50 | > | 90000.0 | nM | - |
| CHEMBL5435212 | — | IC50 | - | — | - | |
| CHEMBL5424693 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5406576 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5419709 | — | IC50 | - | — | - | |
| CHEMBL5434742 | — | IC50 | - | — | - | |
| CHEMBL5436622 | — | IC50 | - | — | - | |
| CHEMBL5411137 | — | IC50 | > | 90000.0 | nM | - |