Assay Detail

CHEMBL5355946

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Functional

Antiproliferative activity against human NB4 cells incubated for 48 hrs

ChEMBL ↗

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Target

NB-4 (CHEMBL614188) ↗

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NB-4 (CHEMBL614188) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NB-4

CHEMBL614188

Anchored from Assay target.

Protein identity NB-4

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NB-4
Confidence	1 — Organism
Curated By	Autocuration

Target

NB-4 (CHEMBL614188) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.

Di Bello E, Sian V, Bontempi G, Zwergel C, Fioravanti R, Noce B, Castiello C, Tomassi S, Corinti D, Passeri D, Pellicciari R, Mercurio C, Varasi M, Altucci L, Tripodi M, Strippoli R, Nebbioso A, Valente S, Mai A.
Eur J Med Chem (2023) 247 : 115022 -115022
PubMed 36549114 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.72	7.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4550522	—	—	1	7.08
CHEMBL5417858	—	—	1	6.68
CHEMBL272980	MOCETINOSTAT	2.0	1	6.39

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4550522	—	IC50	=	84.0	nM	7.08
CHEMBL5417858	—	IC50	=	210.0	nM	6.68
CHEMBL272980	MOCETINOSTAT	IC50	=	406.0	nM	6.39