Assay Detail
Binding
CHEMBL5356087
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Inhibition of phosphotidylserine liposome-stimulated Dynamin 1 (unknown origin) GTPase activity by malachite green assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 4.89 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5400843 | — | — | 1 | 6.00 |
| CHEMBL5397838 | — | — | 1 | 6.00 |
| CHEMBL1198288 | — | — | 1 | 5.82 |
| CHEMBL483059 | — | — | 1 | 5.48 |
| CHEMBL5404798 | — | — | 1 | 5.21 |
| CHEMBL5414459 | — | — | 1 | 5.14 |
| CHEMBL5423066 | — | — | 1 | 5.13 |
| CHEMBL5426248 | — | — | 1 | 5.12 |
| CHEMBL5426975 | — | — | 1 | 5.11 |
| CHEMBL411084 | WISKOSTATIN | — | 1 | 5.11 |
| CHEMBL5421094 | — | — | 1 | 5.10 |
| CHEMBL5408331 | — | — | 1 | 5.06 |
| CHEMBL5433864 | — | — | 1 | 5.05 |
| CHEMBL5436624 | — | — | 1 | 5.04 |
| CHEMBL3774960 | — | — | 1 | 5.04 |
| CHEMBL5405495 | — | — | 1 | 5.01 |
| CHEMBL5410868 | — | — | 1 | 4.98 |
| CHEMBL5406681 | — | — | 1 | 4.96 |
| CHEMBL5396160 | — | — | 1 | 4.94 |
| CHEMBL5410637 | — | — | 1 | 4.94 |
| CHEMBL5399197 | — | — | 1 | 4.91 |
| CHEMBL5416512 | — | — | 1 | 4.89 |
| CHEMBL5409051 | — | — | 1 | 4.89 |
| CHEMBL5399661 | — | — | 1 | 4.87 |
| CHEMBL5427906 | — | — | 1 | 4.86 |
| CHEMBL5424836 | — | — | 1 | 4.82 |
| CHEMBL1416329 | — | — | 1 | 4.81 |
| CHEMBL5401552 | — | — | 1 | 4.78 |
| CHEMBL3544932 | TAK-901 | 1.0 | 1 | 4.76 |
| CHEMBL5421242 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5400843 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5397838 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1198288 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL483059 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5404798 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5414459 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5423066 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5426248 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5426975 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL411084 | WISKOSTATIN | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5421094 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5408331 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5433864 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5436624 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3774960 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5405495 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5410868 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5406681 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5396160 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL5410637 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL5399197 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5416512 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5409051 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL5399661 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL5427906 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL5424836 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1416329 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL5401552 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL3544932 | TAK-901 | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL5421242 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5403810 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL5415712 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL5430142 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL5425127 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL1476463 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL5433264 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL3798017 | (R)-Carvedilol | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL5428698 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL5421744 | — | IC50 | = | 56300.0 | nM | 4.25 |
| CHEMBL589390 | LATREPIRDINE | IC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL5420225 | — | IC50 | = | 61700.0 | nM | 4.21 |
| CHEMBL324665 | CARAZOLOL | IC50 | = | 79700.0 | nM | 4.10 |
| CHEMBL2442630 | — | IC50 | = | 97400.0 | nM | 4.01 |