Assay Detail
ADMET
CHEMBL5356181
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Inhibition of CYP3A4M in human liver microsomes using midazolam as substrate measured after 10 mins in presence of NADPH
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel S-N<sub>3</sub>-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.18 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL655 | MIDAZOLAM | 4.0 | 1 | 7.18 |
| CHEMBL5405590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL655 | MIDAZOLAM | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5405590 | — | IC50 | > | 50000.0 | nM | - |