Assay Detail
Functional
CHEMBL5360314
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Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NB-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural Modification of Noscapine via Photoredox/Nickel Dual Catalysis for the Discovery of S-Phase Arresting Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.98 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423021 | — | — | 1 | 5.28 |
| CHEMBL5420841 | — | — | 1 | 4.98 |
| CHEMBL5410893 | — | — | 1 | 4.97 |
| CHEMBL5427564 | — | — | 1 | 4.88 |
| CHEMBL3323240 | — | — | 1 | 4.79 |
| CHEMBL5431057 | — | — | 1 | - |
| CHEMBL5413927 | — | — | 1 | - |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423021 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL5420841 | — | IC50 | = | 10410.0 | nM | 4.98 |
| CHEMBL5410893 | — | IC50 | = | 10740.0 | nM | 4.97 |
| CHEMBL5427564 | — | IC50 | = | 13240.0 | nM | 4.88 |
| CHEMBL3323240 | — | IC50 | = | 16270.0 | nM | 4.79 |
| CHEMBL5431057 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5413927 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL364713 | NOSCAPINE | IC50 | > | 20000.0 | nM | - |