Assay Detail
Binding
CHEMBL5360967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.01 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431513 | — | — | 1 | 10.68 |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 9.68 |
| CHEMBL2368218 | — | — | 1 | 9.47 |
| CHEMBL100116 | PENTAZOCINE | 4.0 | 1 | 8.49 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 8.49 |
| CHEMBL5401204 | — | — | 1 | 8.46 |
| CHEMBL1186579 | METHYLNALTREXONE | 4.0 | 1 | 8.00 |
| CHEMBL2180640 | — | — | 1 | 6.44 |
| CHEMBL290543 | — | — | 1 | 6.43 |
| CHEMBL5406584 | — | — | 1 | 6.27 |
| CHEMBL4458783 | — | — | 1 | 5.72 |
| CHEMBL5428706 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431513 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL592 | LEVORPHANOL | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL2368218 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL100116 | PENTAZOCINE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL5401204 | — | Ki | = | 3.46 | nM | 8.46 |
| CHEMBL1186579 | METHYLNALTREXONE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2180640 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL290543 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL5406584 | — | Ki | = | 538.0 | nM | 6.27 |
| CHEMBL4458783 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL5428706 | — | Ki | > | 10000.0 | nM | - |