Assay Detail
Functional
CHEMBL5361971
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Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multitargeted drug design strategy for discovery of short-peptide-based HIV-1 entry inhibitors with high potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.58 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413158 | — | — | 1 | 9.12 |
| CHEMBL207004 | — | — | 1 | 9.08 |
| CHEMBL5438380 | — | — | 1 | 8.97 |
| CHEMBL5410204 | — | — | 1 | 7.99 |
| CHEMBL5414303 | — | — | 1 | 7.72 |
| CHEMBL5415654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413158 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL207004 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL5438380 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL5410204 | — | IC50 | = | 10.27 | nM | 7.99 |
| CHEMBL5414303 | — | IC50 | = | 19.17 | nM | 7.72 |
| CHEMBL5415654 | — | IC50 | > | 10000.0 | nM | - |