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Compound Detail

CHEMBL5413158

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Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL5413158
Phase Preclinical
Structure Type MOL
InChI Key GSNHKUDZZFZSJB-XDZVQPMWSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

513.7
MW (Da)
5.95
ALogP
5
HBA
1
HBD
63.0
PSA (Ų)
0.47
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H41F2N5O
MW 513.68
Aromatic Rings 2
Heavy Atoms 37
NP-Likeness -0.85

Activity Summary

IC50 1 meas. best 9.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
C-C chemokine receptor type 5
CHEMBL274
IC50 9.12 9.12 0.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36944281 10.1016/j.ejmech.2023.115294 C-C chemokine receptor type 5 1

Data from ChEMBL 36 via Core Engine