Assay Detail
Binding
CHEMBL5362933
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Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB based Ellman's method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anti-Alzheimer potential of novel α-amino phosphonate derivatives and probing their molecular interaction mechanism with acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.70 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5429003 | — | — | 1 | 4.98 |
| CHEMBL5407606 | — | — | 1 | 4.96 |
| CHEMBL5412970 | — | — | 1 | 4.92 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.79 |
| CHEMBL5420040 | — | — | 1 | 4.73 |
| CHEMBL5433354 | — | — | 1 | 4.69 |
| CHEMBL5402496 | — | — | 1 | 4.63 |
| CHEMBL5405968 | — | — | 1 | 4.58 |
| CHEMBL5430999 | — | — | 1 | 4.53 |
| CHEMBL5433166 | — | — | 1 | 4.47 |
| CHEMBL5416780 | — | — | 1 | 4.45 |
| CHEMBL5424712 | — | — | 1 | - |
| CHEMBL5422865 | — | — | 1 | - |
| CHEMBL5407691 | — | — | 1 | - |
| CHEMBL5415911 | — | — | 1 | - |
| CHEMBL5439155 | — | — | 1 | - |
| CHEMBL5413480 | — | — | 1 | - |
| CHEMBL5426913 | — | — | 1 | - |
| CHEMBL5421943 | — | — | 1 | - |
| CHEMBL5405994 | — | — | 1 | - |
| CHEMBL5424767 | — | — | 1 | - |
| CHEMBL5428540 | — | — | 1 | - |
| CHEMBL5407235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5429003 | — | IC50 | = | 10554.0 | nM | 4.98 |
| CHEMBL5407606 | — | IC50 | = | 11025.0 | nM | 4.96 |
| CHEMBL5412970 | — | IC50 | = | 12052.0 | nM | 4.92 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 16076.0 | nM | 4.79 |
| CHEMBL5420040 | — | IC50 | = | 18678.0 | nM | 4.73 |
| CHEMBL5433354 | — | IC50 | = | 20246.0 | nM | 4.69 |
| CHEMBL5402496 | — | IC50 | = | 23265.0 | nM | 4.63 |
| CHEMBL5405968 | — | IC50 | = | 26432.0 | nM | 4.58 |
| CHEMBL5430999 | — | IC50 | = | 29631.0 | nM | 4.53 |
| CHEMBL5433166 | — | IC50 | = | 33783.0 | nM | 4.47 |
| CHEMBL5416780 | — | IC50 | = | 35365.0 | nM | 4.45 |
| CHEMBL5424712 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5422865 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5407691 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5415911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5439155 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5413480 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5426913 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5421943 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5405994 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5424767 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5428540 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5407235 | — | IC50 | > | 100000.0 | nM | - |