Assay Detail
Functional
CHEMBL5363634
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Cytotoxicity against PD-1 positive human Raji cells measured after 24 hrs by Cell titer glo assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.01 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424446 | — | — | 1 | 7.43 |
| CHEMBL5402920 | — | — | 1 | 6.89 |
| CHEMBL5413702 | — | — | 1 | 6.72 |
| CHEMBL5413938 | — | — | 1 | 6.54 |
| CHEMBL5418307 | — | — | 1 | 6.47 |
| CHEMBL5405378 | — | — | 1 | 6.41 |
| CHEMBL5397651 | — | — | 1 | 6.38 |
| CHEMBL5409835 | — | — | 1 | 6.25 |
| CHEMBL5428120 | — | — | 1 | 6.21 |
| CHEMBL5413446 | — | — | 1 | 6.20 |
| CHEMBL5425590 | — | — | 1 | 6.17 |
| CHEMBL5421560 | — | — | 1 | 5.86 |
| CHEMBL5428379 | — | — | 1 | 5.82 |
| CHEMBL5440311 | — | — | 1 | 5.82 |
| CHEMBL5439568 | — | — | 1 | 5.58 |
| CHEMBL5408449 | — | — | 1 | 5.50 |
| CHEMBL5413192 | — | — | 1 | 5.39 |
| CHEMBL5404056 | — | — | 1 | 5.19 |
| CHEMBL5396683 | — | — | 1 | 5.15 |
| CHEMBL5435688 | — | — | 1 | 5.11 |
| CHEMBL5435778 | — | — | 1 | 5.07 |
| CHEMBL5408311 | — | — | 1 | - |
| CHEMBL5408209 | — | — | 1 | - |
| CHEMBL5401369 | — | — | 1 | - |
| CHEMBL5413144 | — | — | 1 | - |
| CHEMBL5424209 | — | — | 1 | - |
| CHEMBL5417349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424446 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5402920 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5413702 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5413938 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5418307 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5405378 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5397651 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5409835 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5428120 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5413446 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5425590 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5421560 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5428379 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5440311 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5439568 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5408449 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5413192 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5404056 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL5396683 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5435688 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5435778 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5408311 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5408209 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL5401369 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5413144 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5424209 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5417349 | — | IC50 | > | 100000.0 | nM | - |